Infective transmission and characterisation of a C-type virus released by cultured human myeloid leukaemia cells

A C-type virus isolated from long term cultures of myeloid cells from a patient with acute myelogenous leukaemia is infectious for a wide variety of cells. The establishment of chronically infected cells enabled us to characterise the virus by biological, immunological, and biochemical tests. The vi...

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Bibliographic Details
Published in:	Nature (London) Vol. 256; no. 5518; pp. 551 - 555
Main Authors:	Teich, Natalie M, Weiss, Robin A, Salahuddin, S. Zaki, Gallagher, Robert E, Gillespie, David H, Gallo, Robert C
Format:	Journal Article
Language:	English
Published:	England 14-08-1975
Subjects:	Animals Antigens, Viral - analysis Cell Line Chiroptera Cricetinae Cross Reactions Dogs Fibrosarcoma - microbiology Haplorhini Humans Leukemia, Myeloid, Acute - microbiology Mink Quail Rabbits Rats Retroviridae - enzymology Retroviridae - growth & development Retroviridae - immunology Retroviridae - isolation & purification Rhabdomyosarcoma - microbiology RNA-Directed DNA Polymerase - metabolism Satellite Viruses - immunology Viral Plaque Assay Viral Proteins - immunology Virus Replication
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Summary:	A C-type virus isolated from long term cultures of myeloid cells from a patient with acute myelogenous leukaemia is infectious for a wide variety of cells. The establishment of chronically infected cells enabled us to characterise the virus by biological, immunological, and biochemical tests. The virus is closely related to the simian sarcoma-associated virus isolated from a woolly monkey fibrosarcoma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0028-0836 1476-4687
DOI:	10.1038/256551a0