Longitudinal assessment of cardiac status by echocardiographic evaluation of left ventricular diastolic function in thalassaemic children

Cardiac disease is the primary cause of death in patients affected by thalassaemia major. In most cases diastolic dysfunction precedes the onset of systolic impairment at a time when appropriate therapy can prevent progression of cardiac damage. We have assessed the pattern of left ventricular filli...

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Bibliographic Details
Published in:	Acta pædiatrica (Oslo) Vol. 89; no. 4; pp. 436 - 441
Main Authors:	Fiorillo, A, Farina, V, D'Amore, R, Scippa, L, Cortese, P, DeChiara, C
Format:	Journal Article
Language:	English
Published:	Norway 01-04-2000
Subjects:	Adolescent beta-Thalassemia - diagnostic imaging beta-Thalassemia - physiopathology Child Child, Preschool Diastole Disease Progression Echocardiography, Doppler Female Humans Longitudinal Studies Male Ventricular Function, Left
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Summary:	Cardiac disease is the primary cause of death in patients affected by thalassaemia major. In most cases diastolic dysfunction precedes the onset of systolic impairment at a time when appropriate therapy can prevent progression of cardiac damage. We have assessed the pattern of left ventricular filling by Doppler echocardiography in six transfusion-dependent thalassaemic patients. They were re-evaluated 5 y after the first observation, after additional blood transfusions and consequent iron load. We registered a significantly impaired relaxation pattern in all of them. A state of cardiac anoxia has been hypothesized.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0803-5253
DOI:	10.1080/080352500750028159