Association between endothelial biomarkers and lipid and glycemic levels: a cross-sectional study with diabetic patients

• Published in: Biomarkers in medicine Vol. 17; no. 22; pp. 935 - 946
• Main Authors: Medina Néri, Ane Karoline, Silva, Ricardo Pereira, Meneses, Gdayllon Cavalcante, Costa Martins, Alice Maria, Portela Lima, Ana Ofélia, Callou Filho, Cesário Rui, Cavalcante Vidal, Francisco Daniel, de Oliveira Lima, Jeruza Mara, Rocha, Eduardo Arrais, da Silva Júnior, Geraldo Bezerra
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01-11-2023
• Subjects: Biomarkers; Blood Glucose; Cholesterol; Cholesterol, HDL; Cross-Sectional Studies; diabetes mellitus; Diabetes Mellitus, Type 2 - complications; FGFs • glycemic control; Glycated Hemoglobin; Humans; lipids; type 2 diabetes; Vascular Cell Adhesion Molecule-1; lipids; FGFs • glycemic control; diabetes mellitus; type 2 diabetes; biomarkers; vascular cell adhesion molecule-1
• ISSN: 1752-0363; 1752-0371
• DOI: 10.2217/bmm-2023-0174

Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics.
To assess the association between lipid and glycemic profiles and endothelial biomarkers in diabetics.
Cross-sectional study that evaluated lipid and glycemic levels and biomarkers (VCAM-1, Sdc-1, FGF-23 and KIM-1 in diabetics.
Higher VCAM-1 levels were associated with higher low-density lipoprotein cholesterol and non-high-density lipoprotein (HDL) cholesterol levels (in the group with inadequate glycohemoglobin A1c [HbA1c] levels), with higher glycemic levels (in the group with inadequate HDL cholesterol levels) and with lower HDL cholesterol levels (both groups). VCAM-1 was independently associated with not achieving adequate HbA1c levels.
In uncontrolled diabetics, VCAM-1 was independently associated with having inadequate HbA1c levels, suggesting they may already have endothelial damage.