Safety and functional outcome analysis of ventriculoperitoneal shunt placement for hydrocephalus within the critical phase of possible delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

• Published in: Neurosurgical review Vol. 46; no. 1; p. 302
• Main Authors: Jost, Julien N., Irmak, Yasin, Grüter, Basil, Tortora, Angelo, Marbacher, Serge, Musahl, Christian, Schubert, Gerrit A., Andereggen, Lukas, Wanderer, Stefan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 16-11-2023
• Subjects: Brain Ischemia - complications; Brain Ischemia - surgery; Cerebral Infarction - complications; Humans; Hydrocephalus - complications; Hydrocephalus - surgery; Medicine; Medicine & Public Health; Neurosurgery; Retrospective Studies; Subarachnoid Hemorrhage - complications; Subarachnoid Hemorrhage - surgery; Ventriculoperitoneal Shunt - adverse effects; Cerebral vasospasms; Ventriculoperitoneal shunt; Hydrocephalus; Subarachnoid hemorrhage
• ISSN: 1437-2320; 1437-2320
• DOI: 10.1007/s10143-023-02203-0

Shunt-dependent hydrocephalus (HC) is a common sequela following aneurysmal subarachnoid hemorrhage (aSAH). However, there is still poor evidence regarding the optimal timing of ventriculoperitoneal shunt (VPS) placement, particularly in the context of early aSAH-associated complications such as delayed cerebral ischemia (DCI). The purpose of this study was to compare the impact of early (< 21 days after aSAH) versus late (≥ 21 days after aSAH) VPS placement on the functional clinical outcome. We retrospectively analyzed data from 82 patients with VPS placement after aSAH enrolled in our institutional database between 2011 and 2021. We compared two groups, early VPS placement (< 21 days after aSAH) versus late VPS placement (≥ 21 days after aSAH) in terms of demographics, SAH grading, radiological parameters, externalized cerebrospinal fluid diversions, DCI, VPS variables, and functional outcome. We identified 53 patients with early and 29 patients with late VPS implantation. Baseline variables, such as the modified Rankin Scale (mRS), the World Federation of Neurological Surgeons Scale, the Glasgow Coma Scale, and Fisher grade were not significantly different between the groups. Postoperatively, the mRS (
p
 = 0.0037), the Glasgow Outcome Scale (
p
 = 0.0037), and the extended Glasgow Outcome Scale (
p
 = 0.0032) showed significantly better functional results in patients with early cerebrospinal fluid diversion. The rate of DCI did not differ significantly between the groups (
p
 = 0.53). There was no difference in the rate of VPS placement associated complications (
p
 = 0.44) or overall mortality (
p
 = 0.39). Early shunt implantation, within 21 days after aSAH and therefore during the timeframe of possible DCI, might not be harmful in patients developing HC after aSAH.