Infantile hemangioma of the upper eyelid in one very and in two extremely preterm infants

• Published in: Vojnosanitetski pregled Vol. 80; no. 12; pp. 1039 - 1044
• Main Authors: Zeravica, Milica, Matic, Aleksandra, Matic, Milan, Pajic, Milos, Prcic, Sonja
• Format: Journal Article
• Language: English
• Published: Military Health Department, Ministry of Defance, Serbia 2023
• Subjects: drug therapy; eyelids; hemangioma; infant, extremely premature; infant, premature; propranolol
• ISSN: 0042-8450; 2406-0720
• DOI: 10.2298/VSP240402038Z

Introduction. Infantile hemangiomas (IHs) are the most common vascular tumors of infancy whose frequency increases with decreasing gestational age. Although rare, periorbital IHs (PIHs) have a high complication rate, with a substantial risk of impaired vision and aesthetic consequences. Because they are considered high-risk IH, such patients must be treated. In the available literature, there is little information about the treatment o f I Hs in very and extremely preterm newborns and infants. Case report. We present three male infants (one very and two extremely prematurely born) with PIHs involving the upper eyelid. In all three cases, IHs were solitary but with different subtypes according to soft-tissue depth (superficial, combined, deep). No additional congenital anomalies were found in any of these cases. An individualized approach to the management of each patient was applied. All infants were treated with oral administration of propranolol, with careful monitoring for potential side effects of the drug and adjustment of treatment, following their eventual occurrence. The introduction of oral propranolol was carried out in a hospital setting, with a gradual increase of the drug dose until the target dose was reached. Conclusion. In the case of PIH, an ophthalmologist is an inevitable part of the medical team. Very and extremely preterm infants are already under the supervision of an ophthalmologist due to mandatory screening for retinopathy of prematurity; how-ever, if they also have PIHs, monitoring must be particularly detailed and long-lasting.