Fabrication and evaluation of pH-sensitive biocompatible microwave irradiated moringa barkgum-carrageenan (MOG-CRG-IPN) interpenetrating isotropic polymeric network for controlled delivery of pharmaceuticals

• Published in: Sustainable chemistry and pharmacy Vol. 18; p. 100325
• Main Authors: Roy, Debjani, Bal, Trishna, Swain, Sabyasachi
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-12-2020
• Subjects: Carageenan(CRG); Controlled release; Microwave irradiation; Moringa bark gum (MOG); Microwave irradiation; Carageenan(CRG); Moringa bark gum (MOG); Controlled release
• ISSN: 2352-5541; 2352-5541
• DOI: 10.1016/j.scp.2020.100325

In the present research, pH-sensitive interpenetrating polymeric network are prepared by interpenetration of two natural polysaccharides Moringa bark gum(MOG) and Carrageenan (CRG) by use of microwave irradiation as interpenetrating polymeric network (IPN) and characterized using fourier transform infrared spectroscopy(FTIR), x-ray diffraction (XRD), thermogravimetric studies (TGA) and 13C nuclear magnetic resonance (13C NMR) and the surface topography, indepth pore size as well as the interior architecture of the material were confirmed by scanning electron microscopy(SEM) and atomic force microscopy (AFM).The contact angle measurement by optical contact angle (OCA) indicated that the increase in MOG content increased the water retention capacity thereby maintaining the structural integrity of the polymeric network. The pH sensitivity at pH 2,7.4 & 9.2 and swelling studies helped in optimizing the best grade F7.The swelling kinetics of F7 followed second order kinetics. The biodegradability studies were done using soil burial method.The drug release from F7 was found to 88.17% for 8 h interval. The material proved to be hemocompatible. These studies indicated that MOG-CRG-IPN (F7) can be effectively used as an efficient controlled delivery device and can be explored as biomaterial.
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•Isotropic interpenetrating polymeric network of Moringa Bark Gum (MOG)-carageenan(CRG) using microwave irradiation.•The % swelling of F7 has maximum swelling at all pH of 2, 7.4 and 9.2 exhibiting second order swelling kinetics.•Analytical characterizations of F7 with FTIR, 13C NMR, TGA, XRD indicated successful interpenetration between MOG and CRG.•The scanning electron microscopy (SEM) and atomic force microscopy (AFM) of F7 revealed porous surfaces.•The drug release properties of F7 conducted for 8 hours showed 88% release and exhibited hemocompatibility.