Synthesis of pyranopyrazoles using magnetic Fe3O4 nanoparticles as efficient and reusable catalyst
Magnetic Fe3O4 nanoparticles as a heterogeneous catalyst, were found to be efficient for the synthesis of a series of pyranopyrazoles by a four component reaction of a mixture of hydrazine hydrate, ethyl acetoacetate, aldehydes/ketones and malononitrile in water at room temperature. The products wer...
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| Published in: | Tetrahedron Vol. 70; no. 18; pp. 2971 - 2975 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
06-05-2014
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Magnetic Fe3O4 nanoparticles as a heterogeneous catalyst, were found to be efficient for the synthesis of a series of pyranopyrazoles by a four component reaction of a mixture of hydrazine hydrate, ethyl acetoacetate, aldehydes/ketones and malononitrile in water at room temperature. The products were attributed to the nanosize of about 16 nm in which the catalyst could act as a nanoreactor. The present protocol offers the advantages of clean reaction, short reaction time, high yield, easy purification and economic availability of the catalyst.
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| ISSN: | 0040-4020 1464-5416 |
| DOI: | 10.1016/j.tet.2014.03.024 |