Alcohol dehydrogenase and its simple inorganic models

• Published in: Coordination chemistry reviews Vol. 254; no. 7; pp. 916 - 937
• Main Author: Dołęga, Anna
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-04-2010
• Subjects: Alcohol dehydrogenase; Mechanism of action; Model complexes; Structure; Thiolates; ADH; 2,6-Xy; Tp Pic,Me; TriMim; tBuA; p-Tol; BNA +/BNA(Cl)/BNAH; phen; NAD +/NADH; PicCHO; LADH; MDR; Cum; HB(mim o-An ) 2(pz Ph,Me); L S2(Me)N3(Pr); ebnpa; benpa; Tp tBu,Me; Py; bmnpa; Mes; Tp CO2Et,Me; MesCHO; 2-MeIm; aneN 3; Tm 2,6-Xy; FDH; Alcohol dehydrogenase; Tm Tol; PicMeOH; bmpa; Tm Mes; DMEP; Tp tBuA,Me; o-An; H 2MIEH; X 6Et 3Imet 3; Tp Cum,Me; Mechanism of action; Structure; PyCHO; 2-EtIm; bpy; Pic; CO 2Et; CalixN 3ArO; pbnpa; Thiolates; bmapa; Bp Me; Model complexes
• ISSN: 0010-8545; 1873-3840
• DOI: 10.1016/j.ccr.2009.12.039

Despite the long and extensive research, the mechanism of action of zinc-dependent alcohol dehydrogenase on the molecular level is still uncertain. The present state of knowledge of the mechanism of catalytic action of the alcohol dehydrogenase is presented, with the emphasis on the organization of the active site. The other part of the review is devoted to the description of model complexes with particular attention paid to the structural aspect of model studies. Attempts to create an artificial system exhibiting dehydrogenase activity are also described.