Rh-catalyzed novel α-fluoroalkylation of α,β-unsaturated ketones and its mechanism

Treatment of α,β-unsaturated ketones and fluoroalkyl halides with Et 2Zn in the presence of RhCl(PPh 3) 3 gave novel reductive fluoroalkylation products at the α-position of α,β-unsaturated ketones in moderate to good yields. The rhodium hydride complex derived from Et 2Zn and Rh catalyst seems to h...

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Bibliographic Details
Published in:	Tetrahedron Vol. 63; no. 51; pp. 12735 - 12739
Main Authors:	Sato, Kazuyuki, Ishida, Yoshitaka, Murata, Eriko, Oida, Yumiko, Mori, Yasumitsu, Okawa, Miho, Iwase, Kayoko, Tarui, Atsushi, Omote, Masaaki, Kumadaki, Itsumaro, Ando, Akira
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 17-12-2007
Subjects:	Fluorine Fluoroalkyl Rhodium α,β-Unsaturated ketone α-Position Fluoroalkyl α-Position Rhodium Fluorine α,β-Unsaturated ketone
Online Access:	Get full text
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Summary:	Treatment of α,β-unsaturated ketones and fluoroalkyl halides with Et 2Zn in the presence of RhCl(PPh 3) 3 gave novel reductive fluoroalkylation products at the α-position of α,β-unsaturated ketones in moderate to good yields. The rhodium hydride complex derived from Et 2Zn and Rh catalyst seems to have played an important role in this reaction. ▪
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2007.09.081