Iron‐catalyzed construction of cyanomethylated thiohydantoins by cross‐dehydrogenative C(sp3)‐C(sp3) coupling

Iron‐catalyzed construction of cyanomethylated thiohydantoins by cross‐dehydrogenative C(sp3)‐C(sp3) coupling

The efficient and novel approach for synthesizing cyanomethylated thiohydantoin from readily obtainable acetonitrile and 1,3‐dibenzyl‐2‐thiohydantoin through iron(II)‐catalyzed cross dehydrogenative coupling (CDC) protocol is documented here. The strategy displays extensive substrate scope, and prov...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry Vol. 60; no. 3; pp. 449 - 457
Main Authors: Morja, Mayur I., Moradiya, Riddhi B., Makwana, Bhavik S., Chikhalia, Kishor H.
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Inc 01-03-2023
Wiley Subscription Services, Inc
Subjects:
Acetonitrile
Coupling
Dehydrogenation
Iron
Substrates
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The efficient and novel approach for synthesizing cyanomethylated thiohydantoin from readily obtainable acetonitrile and 1,3‐dibenzyl‐2‐thiohydantoin through iron(II)‐catalyzed cross dehydrogenative coupling (CDC) protocol is documented here. The strategy displays extensive substrate scope, and provides an effectual construction of cyanomethylated thiohydantoins in moderate to good yield. Prominently, this new methodology represents hitherto unobserved reactivity pattern for the thiohydantoin.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4599