Microwave Synthesis of Fused Pyrans by Humic Acid Supported Ionic Liquid Catalyst and Their Antimicrobial, Antioxidant, Toxicity Assessment, and Molecular Docking Studies

Microwave Synthesis of Fused Pyrans by Humic Acid Supported Ionic Liquid Catalyst and Their Antimicrobial, Antioxidant, Toxicity Assessment, and Molecular Docking Studies

A series of fused quinolinyl and quinolonyl pyrans were synthesized via a one‐pot reaction of quinolinyl and quinolonyl carbaldehydes, malononitrile, and a 1,3‐diketone. The reactions were catalyzed by a new humic acid supported 1‐butyl‐3‐methyl imidazolium thiocyanate ionic liquid under microwave i...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry Vol. 56; no. 3; pp. 867 - 885
Main Authors: Thangaraj, Muthu, Ranjan, Bibhuti, Muthusamy, Ramesh, Murugesan, Arul, Gengan, Robert Moonsamy
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc 01-03-2019
Subjects:
Antiinfectives and antibacterials
Antioxidants
Chemical reactions
Chemical synthesis
Humic acids
Ionic liquids
Ions
Irradiation
Malononitrile
Molecular docking
Thiocyanates
Toxicity
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Summary:A series of fused quinolinyl and quinolonyl pyrans were synthesized via a one‐pot reaction of quinolinyl and quinolonyl carbaldehydes, malononitrile, and a 1,3‐diketone. The reactions were catalyzed by a new humic acid supported 1‐butyl‐3‐methyl imidazolium thiocyanate ionic liquid under microwave irradiation conditions. Antimicrobial, antioxidant, and toxicity studies displayed various biological activities depending on structure of the pyrans.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3465