Synthesis of an external beta-turn based on the GLDV motif of cell adhesion proteins

Synthesis of an external beta-turn based on the GLDV motif of cell adhesion proteins

The (3 S,6 S,10 S)-7/5 bicyclic lactam 8 , designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser condensation. The cyclic peptide 35 containing the integrin recognition motif GLDV added across the amino and carboxyl groups of the lactam externa...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron Vol. 61; no. 1; pp. 301 - 312
Main Authors: Davies, David E., Doyle, Paul M., Hill, Richard D., Young, Douglas W.
Format: Journal Article
Language:English
Published: Elsevier Ltd 03-01-2005
Subjects:
Bicyclic lactam
Eschenmoser olefination
Integrin
Bicyclic lactam
Eschenmoser olefination
Integrin
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The (3 S,6 S,10 S)-7/5 bicyclic lactam 8 , designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser condensation. The cyclic peptide 35 containing the integrin recognition motif GLDV added across the amino and carboxyl groups of the lactam external constraint 8 was prepared. Graphical Abstract
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2004.09.037