Exploring the design of clinical research studies on the efficacy mechanisms in type 2 diabetes mellitus

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1363877
• Main Authors: Guan, Huifang, Zhao, Shuang, Li, Jiarui, Wang, Ying, Niu, Ping, Zhang, Yuxin, Zhang, Yanjiao, Fang, Xinyi, Miao, Runyu, Tian, Jiaxing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20-09-2024
• Subjects: Biomedical Research - methods; Biomedical Research - trends; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - therapy; Genomics - methods; glycolipid metabolism; Humans; metabolomics; Metabolomics - methods; omics technologies; personalized treatment; Precision Medicine - methods; Proteomics - methods; Research Design; type 2 diabetes mellitus (T2DM); omics technologies; glycolipid metabolism; metabolomics; personalized treatment; type 2 diabetes mellitus (T2DM)
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2024.1363877

This review examines the complexities of Type 2 Diabetes Mellitus (T2DM), focusing on the critical role of integrating omics technologies with traditional experimental methods. It underscores the advancements in understanding the genetic diversity of T2DM and emphasizes the evolution towards personalized treatment modalities. The paper analyzes a variety of omics approaches, including genomics, methylation, transcriptomics, proteomics, metabolomics, and intestinal microbiomics, delineating their substantial contributions to deciphering the multifaceted mechanisms underlying T2DM. Furthermore, the review highlights the indispensable role of non-omics experimental techniques in comprehending and managing T2DM, advocating for their integration in the development of tailored medicine and precision treatment strategies. By identifying existing research gaps and suggesting future research trajectories, the review underscores the necessity for a comprehensive, multidisciplinary approach. This approach synergistically combines clinical insights with cutting-edge biotechnologies, aiming to refine the management and therapeutic interventions of T2DM, and ultimately enhancing patient outcomes. This synthesis of knowledge and methodologies paves the way for innovative advancements in T2DM research, fostering a deeper understanding and more effective treatment of this complex condition.