The rates of abnormal glucose challenge tests and gestational diabetes in women receiving 17α-hydroxyprogesterone caproate

• Published in: American journal of perinatology Vol. 28; no. 10; p. 741
• Main Authors: Wolfe, Katherine, Dearmond, Christine, How, Helen, Henderson, Zsakeba T, Sibai, Baha
• Format: Journal Article
• Language: English
• Published: United States 01-12-2011
• Subjects: Adult; Blood Glucose; Diabetes, Gestational - chemically induced; Dose-Response Relationship, Drug; Female; Glucose Intolerance - chemically induced; Glucose Tolerance Test; Humans; Hydroxyprogesterones - adverse effects; Hydroxyprogesterones - therapeutic use; Logistic Models; Obesity - complications; Pregnancy; Premature Birth - prevention & control; Progestins - adverse effects; Progestins - therapeutic use; Prospective Studies; Secondary Prevention; Young Adult
• ISSN: 1098-8785
• DOI: 10.1055/s-0031-1280854

We compared the rates of abnormal 1-hour glucose challenge tests (GCT) and gestational diabetes (GDM) between women receiving 17α-hydroxyprogesterone caproate (17-P) and women who did not receive 17-P to determine if the effect varies based on the number of doses received or in a group of high-risk obese women. We performed a secondary analysis of a prospective cohort study where women with a history of a previous preterm delivery in the antecedent pregnancy followed at a high-risk clinic were offered 17-P. GCT was performed after the initiation of 17-P, and doses given prior to testing were recorded. Rates of abnormal GCT and GDM were compared between those receiving 17-P ( N = 67) and controls ( N = 140). Mean glucose values (112.4 versus 111.3, P = 0.8), rate of abnormal GCT (23.9% versus 20%, adjusted odds ratio 1.45, 95% confidence interval 0.7 to 3.0), and rate of GDM (6% versus 8.6%, adjusted odds ratio 1.21, 95% confidence interval 0.3 to 4.5) were similar between groups. In this prospective study, 17-P administration to women at risk of recurrent preterm delivery did not significantly affect glucose tolerance.