Bloodstream infections in children caused by extended spectrum beta-lactamase-producing Klebsiella pneumoniae

• Published in: Archives of biological sciences Vol. 64; no. 4; pp. 1339 - 1347
• Main Authors: Medic, Deana, Gusman, Vera, Mihajlovic-Ukropina, Mira, Jelesic, Zora, Milosavljevic, Biljana
• Format: Journal Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2012
• Subjects: antimicrobial resistance; bloodstream infection; children; extended spectrum beta lactamase(ESBL); Klebsiella pneumoniae
• ISSN: 0354-4664; 1821-4339
• DOI: 10.2298/ABS1204339M

The aim of this study is to determine the prevalence of extended spectrum
beta-lactamase (ESBL) producing Klebsiella pneumoniae strains isolated from
blood in children and their susceptibility to antimicrobial drugs commonly
used in the therapy. The study was conducted at the Institute of Public
Health of Vojvodina Province, Serbia, in a two-year period, from January 2009
to December 2010. A total of 424 non-duplicate strains were isolated from the
blood of pediatric patients hospitalized in various wards in the Institute of
Health Care of Children and Youth of Vojvodina Province. Fifty isolates of
Klebsiella pneumoniae were reported. The frequency of isolation of Klebsiella
pneumoniae was 27/222 (12.2%) and 23/202 (11.3%) isolates in 2009 and 2010,
respectively. There was a high prevalence of ESBL-producing Klebsiella
pneumoniae, 76% (38/50), and 17 isolates (44.7%) were multidrug resistant
(MDR). Further drug resistance surveillance in hospitals and the molecular
characterization of ESBL-positive isolates in our country is necessary.
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