Antiviral activity of colostrum and serum immunoglobulins A and G

Enteric virus-specific IgA and IgG present in paired human sera and colostrums were measured by the enzyme-linked immunosorbent assay (ELISA). Virus-specific IgA was present in all colostrums, but virus-specific IgG could not be detected. The reverse was true when sera were assayed. Most of these co...

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Bibliographic Details
Published in:	Journal of medical virology Vol. 5; no. 2; p. 123
Main Authors:	Palmer, E L, Gary, Jr, G W, Black, R, Martin, M L
Format:	Journal Article
Language:	English
Published:	United States 1980
Subjects:	Antibodies, Viral - isolation & purification Antibody Specificity Colostrum - immunology Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin A - immunology Immunoglobulin G - immunology Poliovirus - immunology Reoviridae - immunology Rotavirus - immunology Serum Globulins - analysis Serum Globulins - immunology
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Summary:	Enteric virus-specific IgA and IgG present in paired human sera and colostrums were measured by the enzyme-linked immunosorbent assay (ELISA). Virus-specific IgA was present in all colostrums, but virus-specific IgG could not be detected. The reverse was true when sera were assayed. Most of these colostrums also neutralized either polio virus or reovirus, as did IgA, which was separated from a pool of colostrums by exclusion chromatography. No correlation could be made between levels of neutralizing and ELISA antibody titers in colostrums.
ISSN:	0146-6615
DOI:	10.1002/jmv.1890050205