Consistent presence of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new cytogenetic-clinicopathologic entity

• Published in: Genes chromosomes & cancer Vol. 12; no. 3; p. 161
• Main Authors: Wang, C C, Tien, H F, Lin, M T, Su, I J, Wang, C H, Chuang, S M, Shen, M C, Liu, C H
• Format: Journal Article
• Language: English
• Published: United States 01-03-1995
• Subjects: Adult; Antigens, CD - analysis; Bone Marrow - immunology; Bone Marrow - pathology; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; Fatal Outcome; Genetic Markers; Humans; Isochromosomes; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Lymphoma, T-Cell, Peripheral - genetics; Lymphoma, T-Cell, Peripheral - immunology; Male; Receptors, Antigen, T-Cell, gamma-delta - analysis; Spleen - immunology; Spleen - pathology; Splenic Neoplasms - genetics; Splenic Neoplasms - immunology; Trisomy
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870120302

Peripheral T-cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the gamma/delta T-cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non-Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T gamma/delta cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T gamma/delta PTL.