Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway

[Display omitted] •Agomelatine increased renal SIRT1 expression in STZ-treated rats.•Agomelatine improved diabetes and insulin resistance.•Agomelatine improved renal histology, function, and inflammation in diabetic rats.•Agomelatine reduced NFκB and increased AMPK phosphorylation in kidney.•The eff...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 115; p. 109646
Main Authors:	Mahmoud, Nevertyty M., Elshazly, Shimaa M., Hassan, Arwa A., Soliman, Eman
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-02-2023
Subjects:	Agomelatine AMP-Activated Protein Kinases - metabolism AMPK Animals Anti-Inflammatory Agents - pharmacology Diabetes Mellitus, Experimental - metabolism Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diabetic nephropathy Intercellular Adhesion Molecule-1 Kidney Failure, Chronic Male Melatonin - pharmacology Melatonin - therapeutic use Melatonin receptors NF-kappa B - metabolism NFκB Rats Rats, Wistar Receptors, Melatonin - therapeutic use Signal Transduction SIRT1 Sirtuin 1 - metabolism Streptozocin Vascular Cell Adhesion Molecule-1 Melatonin receptors ESRD MCP-1 NFκB DAB IHC H&E MT AGO DN ICAM-1 SIRT1 LPS HOMA-IR VCAM-1 CMC STZ Diabetic nephropathy AMPK Agomelatine GlcNAc ELISA
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