Corticospinal excitability enhancement with simultaneous transcranial near-infrared stimulation and anodal direct current stimulation of motor cortex

• Published in: Clinical neurophysiology Vol. 132; no. 5; pp. 1018 - 1024
• Main Authors: Song, Penghui, Li, Siran, Hao, Wensi, Wei, Min, Liu, Jianghong, Lin, Hua, Hu, Shimin, Dai, Xiaona, Wang, Jing, Wang, Rong, Wang, Yuping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-05-2021
• Subjects: Cortical excitability; Motor evoked potentials; Simultaneous; Transcranial direct current stimulation; Transcranial near-infrared stimulation; Cortical excitability; NIBS; LTP; FDI; Motor evoked potentials; Transcranial direct current stimulation; CCO; sTMS; tDCS; tNIRS; RMT; NMDA; TMS; Transcranial near-infrared stimulation; Simultaneous; ATP; LTD
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2021.01.020

•Anodal transcranial direct current stimulation (tDCS) alone and transcranial near-infrared stimulation (tNIRS) alone both enhance corticospinal excitability.•Simultanous tNIRS and tDCS enhance corticospinal excitability stronger than either one of the single interventions.•Simultanous tNIRS and tDCS is a promising new brain stimulation method for clinical neuroplasticity research.
Non-invasive brain stimulation (NIBS) is beneficial to many neurological and psychiatric disorders by modulating neuroplasticity and cortical excitability. However, recent studies evidence that single type of NIBS such as transcranial direct current stimulation (tDCS) does not have meaningful clinical therapeutic responses due to their small effect size. Transcranial near-infrared stimulation (tNIRS) is a novel form of NIBS. Both tNIRS and tDCS implement its therapeutic effects by modulating cortical excitability but with different mechanisms. We hypothesized that simultaneous tNIRS and tDCS is superior to single stimulation, leading to a greater cortical excitability.
Sixteen healthy subjects participated in a double-blind, sham-controlled, cross-over designed study. Motor evoked potentials (MEPs) were used to measure motor cortex excitability. The changes of MEP were calculated and compared in the sham condition, tDCS stimulation condition, tNIRS condition and the simultaneous tNIRS and anodal tDCS condition.
tDCS alone and tNIRS alone both elicited higher MEP after stimulation, while the MEP amplitude in the simultaneous tNIRS and tDCS condition was significantly higher than either tNIRS alone or tDCS alone. The enhancement lasted up to at least 30 minutes after stimulation, indicating simultaneous 820 nm tNIRS with 2 mA anodal tDCS have a synergistic effect on cortical plasticity.
Simultaneous application of tNIRS with tDCS produces a stronger cortical excitability effect.
The simultaneous tNIRS and tDCS is a promising technology with exciting potential as a means of treatment, neuro-enhancement, or neuro-protection.