A Radiologist's Guide to the Changing Treatment Paradigm of Advanced Non-Small Cell Lung Cancer: The ASCO 2018 Molecular Testing Guidelines and Targeted Therapies

• Published in: American journal of roentgenology (1976) Vol. 213; no. 5; pp. 1047 - 1058
• Main Authors: Chen, Lydia, Smith, Daniel A, Somarouthu, Bhanusupriya, Gupta, Amit, Gilani, Kianoush Ansari, Ramaiya, Nikhil H
• Format: Journal Article
• Language: English
• Published: United States 01-11-2019
• Subjects: Biomarkers, Tumor - genetics; Carcinoma, Non-Small-Cell Lung - diagnostic imaging; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Genomics; Humans; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Molecular Targeted Therapy; Mutation; Precision Medicine; United States; United States; ALK; mutational profiling; targeted therapies; molecular testing; oncologic imaging; non–small cell lung cancer; EGFR
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/AJR.19.21135

The purpose of this article is to provide an imaging-based guide of the modern genomic classifications and targeted therapies for advanced non-small cell lung cancer (NSCLC) with an emphasis on the relevance of the 2018 American Society of Clinical Oncology molecular testing guidelines for radiologists.
Knowledge of the radiologic relevance of lung cancer driver mutations and modern targeted agents is essential for imaging interpretation of advanced NSCLC in the modern age of precision medicine.