Distribution and Identity of Thy-1-Bearing Cells during Ontogeny in Rat Hemopoietic and Lymphoid Tissues

The distribution and identity of Thy-1+ cells during ontogeny in the rat were examined by immunofluorescent and histologic techniques, and the relative amount of Thy-1 antigen on different cell types was assessed by quantitative absorption. Thy-1+ cells were subsequently studied by dual immunofluore...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 121; no. 6; pp. 2463 - 2471
Main Authors:	Ritter, Mary A, Gordon, Lance K, Goldschneider, Irving
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-12-1978
Subjects:	Animals Female Fetus - immunology Hematopoietic Stem Cells - immunology Isoantigens Liver - immunology Lymphoid Tissue - immunology Male Pregnancy Rabbits Rats Rats, Inbred Lew Receptors, Antigen, B-Cell Spleen - immunology T-Lymphocytes - immunology Thymus Gland - immunology
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Summary:	The distribution and identity of Thy-1+ cells during ontogeny in the rat were examined by immunofluorescent and histologic techniques, and the relative amount of Thy-1 antigen on different cell types was assessed by quantitative absorption. Thy-1+ cells were subsequently studied by dual immunofluorescence for the simultaneous expression of either T or B lymphocyte markers. The results indicate that the Thy-1 antigen is present on hemopoietic precursors and on at least some of their lymphoid (both T and B) and nonlymphoid descendants. In addition, six serologically distinct subpopulations of lymphoid cells were identified, and their position in T and B cell maturational pathways is discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.121.6.2463