Ifosfamide causes a diazepam-sensitive encephalopathy

An encephalopathy characterized by confusion, stupor, and mutism frequently occurs during administration of the chemotherapeutic drug ifosfamide (IFX). We investigated two patients who developed encephalopathy during IFX infusion. Both exhibited a rapid and near-complete restoration of baseline ment...

Full description

Saved in:

Bibliographic Details
Published in:	Neurology Vol. 43; no. 12; p. 2700
Main Authors:	Simonian, N A, Gilliam, F G, Chiappa, K H
Format:	Journal Article
Language:	English
Published:	United States 01-12-1993
Subjects:	Adult Brain Diseases - chemically induced Brain Diseases - drug therapy Brain Diseases - physiopathology Consciousness - drug effects Diazepam - therapeutic use Electroencephalography Female Humans Ifosfamide - adverse effects Middle Aged Mutism - diagnosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	An encephalopathy characterized by confusion, stupor, and mutism frequently occurs during administration of the chemotherapeutic drug ifosfamide (IFX). We investigated two patients who developed encephalopathy during IFX infusion. Both exhibited a rapid and near-complete restoration of baseline mental status functioning concurrent with EEG improvement after administration of intravenous diazepam. We recommend an EEG and trial of benzodiazepines in patients with IFX encephalopathy.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.43.12.2700