Inhibitory effect of polynucleotides on solid tumor produced in mice by Ehrlich ascites cancer cells

Solid tumors produced in mice by Ehrlich ascites cancer cells were completely regressed by treatment with the copolymer of polyriboinosinic acid-polyribocytidylic acid (poly (I):(C)) when 200 microgram of this compound was intravenously injected 3 times a week for 3-4 weeks, starting 7-8 days after...

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Bibliographic Details
Published in:	Journal of interferon research Vol. 2; no. 1; p. 103
Main Authors:	Nagano, Y, Takano, S
Format:	Journal Article
Language:	English
Published:	United States 1982
Subjects:	Animals Carcinoma, Ehrlich Tumor - metabolism Dose-Response Relationship, Drug Injections, Intravenous Interferons - biosynthesis Male Mice Poly I-C - administration & dosage Poly I-C - pharmacology
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Summary:	Solid tumors produced in mice by Ehrlich ascites cancer cells were completely regressed by treatment with the copolymer of polyriboinosinic acid-polyribocytidylic acid (poly (I):(C)) when 200 microgram of this compound was intravenously injected 3 times a week for 3-4 weeks, starting 7-8 days after transplantation of the tumor. Although the first injection of poly (I):(C) caused hyporeactivity to re-induction of IFN, the subsequent 6 doses stimulated the formation of IFN at 3685 units/ml on average after each injection, strongly suggesting that IFN plays a role in the antitumoral effect of poly (I):(C).
ISSN:	0197-8357
DOI:	10.1089/jir.1982.2.103