Behavior and Outcomes of Pregnancy Associated Breast Cancer

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 20; no. 1; pp. 135 - 138
• Main Authors: Suleman, Kausar, Osmani, Asif Husain, Al Hashem, Hashem, Al Twegieri, Taher, Ajarim, Dahish, Jastaniyah, Noha, Al Khayal, Wafa, Al Malik, Osama, Al Sayed, Adhar
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01-01-2019
• Subjects: Adult; Disease-Free Survival; Female; Humans; Middle Aged; Pregnancy; Pregnancy Complications, Neoplastic - diagnosis; Pregnancy Complications, Neoplastic - metabolism; Pregnancy Complications, Neoplastic - mortality; Pregnancy Complications, Neoplastic - pathology; Prognosis; Prospective Studies; Receptor, ErbB-2 - metabolism; Receptors, Estrogen - metabolism; Receptors, Progesterone - metabolism; Retrospective Studies; Saudi Arabia; Survival Rate; Tertiary Care Centers; Triple Negative Breast Neoplasms - diagnosis; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - mortality; Triple Negative Breast Neoplasms - pathology; Young Adult; Saudi Arabia; pregnancy associated breast cancer (PABC); prognosis; Breast cancer (BC); pregnancy
• ISSN: 1513-7368; 2476-762X
• DOI: 10.31557/APJCP.2019.20.1.135

Introduction: Pregnancy Associated Breast cancer (PABC) is associated with poor prognosis and a decreased overall
survival. A retrospective review was conducted to review the experience and outcome in a tertiary care hospital, and to
compare those seen in a matched group for year of diagnosis. Materials and Methods: This is a retrospective review
of a prospectively collected breast cancer registry. The study was conducted in a tertiary care hospital in Riyadh, Saudi
Arabia from January to Decamber 2014 . Female patients with PABC were identified and matched with similar cohort
of non-pregnant breast cancer patients that were diagnosed between 2001-2010. Clinical data including age, tumor
biology, clinical stage, follow up and outcomes (disease free survival, DFS) were analyzed and compared between the
two groups using SAS 9.3 and R-2.14.1 Results: A total of 110 patients in Group 1 and 114 patients in Group II were
analyzed. In both groups, the patient age ranged was between 20 to 45 years; the median follow up was 34 months in
PABC and 54 months in non-pregnant cohort. PABC were statistically more likely to be triple negative (p value-0.05) and
diagnosed at advanced stage (stage 3 and 4) (p value-0.02). There was no difference in the occurrence of Her-2 positive
disease. In pregnant patients there was a 5-year survival rate of 65% compared to non-pregnant cohort of 82% with p
value of 0.002 and DFS was also 47.5% versus 65.4% with a p value .002 which is statistically significant. Conclusion:
Pregnancy associated breast cancer (PABC) is diagnosed at a more advanced stage and tends to be triple negative and
they are associated with a worse DFS and overall survival. Early detection during pregnancy may improve outcome.