Biochemical assessment of lead, phenol, and benzene-contaminated water on the heart and blood of Albino rats

• Published in: Toxicological and environmental chemistry Vol. 92; no. 7; pp. 1347 - 1356
• Main Authors: Adeyemi, O., Adenitire, G.S., Oloyede, O.B., Oladiji, A.T., Oluba, O.M., Ololade, I.A., Adebayo, E.A.
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis Group 01-08-2010; Taylor & Francis Ltd
• Subjects: atherosclerosis; Biochemistry; Blood; Contamination; Enzymes; eosinophils; Heart; Lead; lipoproteins; phosphatases; Polyphenols; Rodents; Tissues; Water quality
• ISSN: 0277-2248; 1029-0486
• DOI: 10.1080/02772240903362451

A study was performed to evaluate the effect of contaminated water on the tissues of Rattus novergicus (albino rats). Test rats were given water contaminated with lead (0.015 µg L
−1
tap water), phenol (0.05 mL L
−1
tap water), and benzene (0.05 mL L
−1
tap water), while control rats were given tap water over a period of 65 days after which the activity of selected enzymes of the heart and serum was assayed, and hematological parameters and serum lipid profiles were also determined. Generally, a significant (p < 0.05) drop in the activity of the enzymes was observed in the heart of test rats relative to the control rats. However, the serum activities increased significantly in the test group compared to the control group (p < 0.05). The concentrations of serum cholesterol, low-density lipoprotein (LDL), and triglycerides of the test rats were found to be significantly higher than those of the control rats (p < 0.05). Concentrations of hemoglobin, red blood cell count, and packed cell volume of test rats were observed to be significantly lower than those of the control rats (p < 0.05). The experimental results indicated that consumption of water contaminated with lead, phenol, and benzene may damage the heart, increase the risk of atherosclerosis as reflected by the serum lipid profile, and anemia as suggested by abnormal hematological properties.