Detection of oxandrolone and its metabolite in urine by high-performance liquid chromatography-high-resolution mass spectrometry with atmospheric pressure chemical ionization and orbitrap detection after ceasing drug administration

Detection of oxandrolone and its metabolite in urine by high-performance liquid chromatography-high-resolution mass spectrometry with atmospheric pressure chemical ionization and orbitrap detection after ceasing drug administration

It was shown that oxandrolone can be detected by high-performance liquid chromatography-high-resolution mass spectrometry with atmospheric pressure chemical ionization and orbitrap detection up to two weeks after ceasing its administration. The mass accuracy in the analysis of real samples was 2 ppm...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) Vol. 64; no. 1; pp. 31 - 35
Main Authors: Viryus, E. D., Sobolevskii, T. G., Rodchenkov, G. M.
Format: Journal Article
Language:English
Published: Dordrecht SP MAIK Nauka/Interperiodica 2009
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Doping Control
Oxandrolone
Anabolic Steroid
Mass Chromatogram
Mass Accuracy
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Summary:It was shown that oxandrolone can be detected by high-performance liquid chromatography-high-resolution mass spectrometry with atmospheric pressure chemical ionization and orbitrap detection up to two weeks after ceasing its administration. The mass accuracy in the analysis of real samples was 2 ppm. The detection limits for oxandrolone and its metabolite were 3 and 1 pg/mL, respectively (signal-to-noise ratio of 10).
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934809010079