Synthesis of some new 2,6-disubstituted-3(2H)-pyridazinone derivatives and investigation of their analgesic, anti-inflammatory and antimicrobial activities

• Published in: Medicinal chemistry research Vol. 22; no. 6; pp. 2553 - 2560
• Main Authors: Tiryaki, Didem, Sukuroglu, Murat, Dogruer, Deniz S., Akkol, Esra, Ozgen, Selda, Sahin, M. Fethi
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01-06-2013
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Original Research; Pharmacology/Toxicology; Anti-inflammatory activity; Antimicrobial activity; 3; Analgesic activity; pyridazinone
• ISSN: 1054-2523; 1554-8120
• DOI: 10.1007/s00044-012-0253-1

In this study, 12 new 3(2
H
)-pyridazinone derivatives carrying 4-substituted phenylpiperazinylethyl moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by
1
H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound
9c
showed the best analgesic and anti-inflammatory activities without causing any gastric effect in stomachs of tested animals. In addition, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.