Association between Allelic Variants of IL2, IL2RA, and IL7R Genes and Multiple Sclerosis

• Published in: Russian journal of genetics Vol. 55; no. 4; pp. 487 - 494
• Main Authors: Timasheva, Y. R., Zaplakhova, O. V., Nasibullin, T. R., Tuktarova, I. A., Erdman, V. V., Bakhtiiarova, K. Z., Mustafina, O. E.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-04-2019
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Human Genetics; Microbial Genetics and Genomics; interleukin-7 receptor alpha chain; genetic polymorphism; multiple sclerosis; association study; interleukins
• ISSN: 1022-7954; 1608-3369
• DOI: 10.1134/S1022795419030153

Multiple sclerosis is a chronic progressive disease of nervous system caused by a combination of genetic and environmental factors leading to the development of a complex of autoimmune and neurodegenerative processes. We performed the analysis of association between multiple sclerosis and polymorphic markers of interleukin-2 (
IL2
), interleukin-2 receptor alpha chain (
IL2A
) and interleukin-7 receptor alpha chain (
IL7R
) in the group of Russians, Tatars, and Bashkirs from the Republic of Bashkortostan (
N
= 1620). In the total study group, we detected the association of
IL7R
rs10624573*I (OR = 0.79,
P
Bonf
= 0.018) and rs1494558*T (OR = 1.44,
P
Bonf
= 2.33 × 10
–4
) variants with multiple sclerosis. When analyzed separately according to the ethnic origin, the association with
IL7R
rs1494558*T (OR = 1.49, P
Bonf
= 0.005) remained significant in the group of Russians, and the association of
IL7R
rs10624573*I remained significant in the group of Bashkirs (OR = 0.56,
P
Bonf
= 0.02). We performed the multilocus analysis of association using the APSampler algorithm, and found seven combinations of the alleles and/or genotypes of the studied polymorphic loci, significantly associated with multiple sclerosis, most frequently including
IL7R
rs1494558 and
IL7R
rs10624573 allelic variants.