Novel metabolically stable and functionally active mimetic of spermidine

Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of γ-MeSpd pr...

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Bibliographic Details
Published in:	Russian journal of bioorganic chemistry Vol. 37; no. 2; pp. 225 - 230
Main Authors:	Khomutov, M. A., Hyvönen, M. T., Simonian, A. R., Vepsäläinen, J., Alhonen, L., Kochetkov, S. N., Keinänen, T. A.
Format:	Journal Article
Language:	English
Published:	Dordrecht SP MAIK Nauka/Interperiodica 01-03-2011
Subjects:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry DU145 cells spermine synthase γ-MeSpd spermidine analogues polyamines acetyltransferase spermine/spermidine N
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Summary:	Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of γ-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.
ISSN:	1068-1620 1608-330X
DOI:	10.1134/S1068162011020075