Sulfanylamide-containing coordination compounds of 3d-elements with 2,4-pentanedione bis-thiosemicarbazone and bis-4-phenylthiosemicarbazone

• Published in: Russian journal of general chemistry Vol. 78; no. 5; pp. 984 - 990
• Main Authors: Gulya, A. P., Spynu, S. N., Tsapkov, V. I., Poirer, D.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01-05-2008
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Thiosemicarbazide; General Chemistry; Coordination Compound; Sulfanyl; Thiosemicarbazones
• ISSN: 1070-3632; 1608-3350
• DOI: 10.1134/S1070363208050253

Thiosemicarbazide and 4-phenylthiosemicarbazide react in ethanol with 2,4-pentanedione in the presence of manganese, cobalt, nickel, copper, and zinc acetates hydrates and streptamin (Sf
1
), sulfaethidole (Sf
2
), and sulfadimidine (Sf
3
) to form coordination compounds of the composition M(Sf
1–3
)(L
1–2
) ·
n
H
2
O (M = Mn, Co, Ni, Cu, Zn; H
2
L
1
is 2,4-pentanedione bis-thiosemicarbazone, H
2
L
2
is 2,4-pentanedione bis-4-phenylthiosemicarbazone;
n
= 0–6). All the complexes synthesized are monomeric. Thiosemicarbazones (H
2
L
1
and H
2
L
2
) behave as twice deprotonated S,N,N,S-tetradentate ligands, while sulfanylamides (Sf
1–3
) act as monodentate ones. Thermolysis of these substances proceeds through the stages of dehydration (65–95°C) and complete thermal decomposition (430–560°C). It is found that the complex [Cu(Sf
2
)(L
1
)] · 4H
2
O in the concentration 10
−5
M inhibits the growth and fission of 100% cancer cells of the human myeloid leukemia (HL-60).