Studies on Antiviral Glycosides. 4. Inhibition of the Multiplication of Paramyxoviruses by Phenyl-6-chloro-6-deoxy-beta-D-glucopyranoside

• Published in: Journal of general virology Vol. 45; no. 1; pp. 249 - 251
• Main Authors: Sugita, Kenji, Arita, Hitoshi, Kawanami, Jun'ichi, Sato, Kosaburo
• Format: Journal Article
• Language: English
• Published: England Soc General Microbiol 01-10-1979
• Subjects: Antiviral Agents - pharmacology; Glucosides - pharmacology; Glycosides - pharmacology; Measles virus - drug effects; Newcastle disease virus - drug effects; Orthomyxoviridae - drug effects; Parainfluenza Virus 1, Human - drug effects; Poliovirus - drug effects; RNA, Viral - biosynthesis; Vesicular stomatitis Indiana virus - drug effects; Viral Proteins - biosynthesis
• ISSN: 0022-1317; 1465-2099
• DOI: 10.1099/0022-1317-45-1-249

Shionogi Research Laboratory Shionogi & Co., Ltd. Fukushima-ku, Osaka 553, Japan
The antiviral activity of phenyl-6-chloro-6-deoxy- - D -glucopyranoside (PCG) was studied. PCG specifically inhibited the growth of paramyxoviruses including Sendai, measles and Newcastle disease viruses in LLCMK 2 cells at a concentration of 0.5 to 1.0 m M , but did not restrict the multiplication of other RNA viruses (influenza, vesicular stomatitis and polio viruses) at these concentrations.
PCG might act in the late stage during virus replication of Sendai virus as it did not inhibit virus RNA and protein synthesis in the infected cells. Comparative studies on the biological properties of virus particles grown in the presence and absence of PCG demonstrated that treatment with it caused the formation of non-haemagglutinating particles.
* To whom reprint requests should be addressed.
Deceased.
Received 25 October 1978;
accepted 20 June 1979.