Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 78; no. 2; pp. 241 - 251
• Main Authors: Turner, Shira T., Focht, Gili, Orlanski‐Meyer, Esther, Lev‐Tzion, Raffi, Ledder, Oren, Yogev, Dotan, Assa, Amit, Shaoul, Ron, Crowely, Eileen, Otley, Anthony, Griffiths, Anne M., Turner, Dan
• Format: Journal Article
• Language: English
• Published: United States 01-02-2024
• Subjects: Crohn's disease; fatigue; pediatric inflammatory bowel diseases; ulcerative colitis; fatigue; pediatric inflammatory bowel diseases; Crohn's disease; ulcerative colitis
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1002/jpn3.12039

Objectives
We aimed to review the literature on fatigue in pediatric inflammatory bowel diseases (PIBD), to explore how it is measured, and approximate its rate in an inception pediatric cohort.
Methods
Studies on fatigue were systematically reviewed and selected by two authors. Next, we retrieved the two fatigue‐related questions of the IMPACT‐III questionnaire at 4 and 12 months after diagnosis from a prospectively maintained cohort of PIBD patients, each scoring 0‐100 (lower scores imply more fatigue), and 44 healthy controls.
Results
The systematic review identified 14 studies reporting fatigue in children, of which nine had fatigue as the primary outcome and only two provided rates of fatigue. No standalone index was identified for measuring fatigue specifically for PIBD. Of 80 children included in the inception cohort, 62 (78%) scored an average of ≤75 on the two IMPACT‐III questions (approximating at least mild fatigue), 26 (33%) scored ≤50 (at least moderate fatigue) and nine (11%) scored ≤25 (severe fatigue). In comparison, only four (9%) healthy children scored at least moderate fatigue (p = 0.007). Fatigue rates at 12 months were only slightly and nonsignificantly lower. Fatigue of any severity was reported in 92% children with active disease versus 63% of those in clinical remission (p = 0.01).
Conclusion
Literature reporting on fatigue in PIBD is scarce, and no PIBD‐specific tool is available to measure fatigue. In our cohort, fatigue‐related questions were frequently scored low in children with IBD, mainly among children with active disease but also during clinical remission.
Fatigue in pediatric inflammatory bowel diseases: a systematic review and a single center experience.
What is Known
In a systematic review of the literature, only 14 studies reported fatigue in children with IBD, of which only two reported the rate of severe fatigue.
This is the first study to explore grades of fatigue amongst pediatric IBD, showing 33% of at least moderate fatigue, compared with 9% in healthy controls.
Fatigue was more frequent in children with active disease but was also common during clinical remission.
What is New
Fatigue, a well‐recognized symptom of inflammatory bowel disease, has a broad implications on quality of life and disability.
Yet it is often unrecognized during clinic visits.
Unlike for adults, there is no pediatric‐specific tool to measure fatigue in children with IBD.