Impact of NB‐UVB phototherapy on Caveolin‐1 expression in chronic plaque psoriasis

• Published in: Photodermatology, photoimmunology & photomedicine Vol. 39; no. 3; pp. 218 - 225
• Main Authors: Elsherbeni, Marwa B., Neinaa, Yomna Mazid El‐Hamd, Fawzy, Mohamed M., Elwan, Nagwa M.
• Format: Journal Article
• Language: English
• Published: England 01-05-2023
• Subjects: Caveolin 1 - therapeutic use; Cav‐1; ESI score; Humans; NB‐UVB phototherapy; PASI score; Phototherapy; psoriasis; Psoriasis - drug therapy; Psoriasis - radiotherapy; Treatment Outcome; Ultraviolet Therapy; Cav-1; PASI score; ESI score; NB-UVB phototherapy; psoriasis
• ISSN: 0905-4383; 1600-0781
• DOI: 10.1111/phpp.12822

Background
Caveolin‐1 (Cav‐1) is a significant structural and regulatory constituent of cell membranes that has been implicated in cell kinetics and inflammation.
Objective
To assess Cav‐1 expression in psoriasis before and after phototherapy.
Patients and methods
Thirty psoriasis cases and 30 healthy controls were recruited. Cases were managed with narrow band‐ultraviolet B (NB‐UVB) phototherapy at frequency three times per week for 12 weeks. From every case, two biopsy specimens were gained from psoriatic lesions (pre and post phototherapy), in addition to one from apparently normal skin of psoriasis cases. Regarding the control group, one biopsy was taken from a matched site. All were studied for Cav‐1 antibody immuno‐expression.
Results
There was a significant decrease in Cav‐1 expression in psoriatic lesions compared to both the apparently normal skin of psoriasis patients and standard control skin of healthy individuals. After NB‐UVB phototherapy, significant upregulation of Cav‐1 immunostaining score was observed in previously psoriatic skin when compared to that before treatment. In addition, there were significant negative correlations between Cav‐1 immunostaining score and the clinical scores of psoriasis severity including; the erythema, scaling, and induration (ESI) score and the patient psoriasis area and severity index (PASI) score.
Conclusion
Induction of Cav‐1 expression may be a likely pathway for the effectiveness of NB‐UVB in psoriasis. Cav‐1 may be a useful marker for evaluation of psoriasis severity, disease progression, and therapeutic efficacy.