Cornual adenomyosis in Essure® device users and in patients hysterectomized for other causes: A retrospective cohort study

• Published in: International journal of gynecology and obstetrics Vol. 167; no. 1; pp. 185 - 190
• Main Authors: Sánchez‐Cuerda, Cristina, Elices, Margarita, Lobo, Paloma, Cabrera, Yasmina, Duch, Silvia, García, Alicia, Rubio, José, Álvarez, Julio, Álvarez, Pilar
• Format: Journal Article
• Language: English
• Published: United States 01-10-2024
• Subjects: adenomyosis; cornual adenomyosis; Essure; hysterectomy; pelvic pain; removal; cornual adenomyosis; removal; Essure; pelvic pain; adenomyosis; hysterectomy
• ISSN: 0020-7292; 1879-3479; 1879-3479
• DOI: 10.1002/ijgo.15541

Objective
To determine whether adenomyosis is present in the cornual portion of hysterectomies of symptomatic sterilization device users and in patients hysterectomized for different benign causes and who presented with pelvic pain and/or menstrual alterations.
Methods
An observational, analytical, cross‐sectional, single‐center, retrospective cohort study was conducted in a secondary level hospital. Cohort 1 consisted of women who had Essure® hysteroscopic sterilization devices inserted between 2009 and 2017, who developed gynecologic symptoms (pelvic pain, heavy menstrual bleeding, and/or abnormal uterine bleeding) and who underwent a hysterectomy for explantation of the devices. Cohort 2 consisted of women with the same gynecologic symptoms, who underwent a hysterectomy for other benign causes. All surgeries were performed by the gynecology team between 2018 and 2022. A descriptive and comparative analysis of sociodemographic, clinical characteristics, and pathologic findings between cohorts was made.
Results
In total, 96 patients were studied (cohort 1 included 34 women, cohort 2 included 62 women). Pelvic pain was found to be more frequent in the cohort of Essure users (76.47% vs. 50%, P = 0.012), with a ratio of three times higher in this group (odds ratio 3.25, 95% confidence interval 1.27–8.28). Adenomyosis was more frequently found in the Essure group, both at corporal and cornual portions, the latter being five times higher in this cohort (relative risk = 5.47; 95% confidence interval 1.17–25.64).
Conclusions
The present study may be the first to describe cornual adenomyosis related to Essure devices. These devices may play a role in the development of adenomyosis and, consequently, pelvic pain. However, causality is difficult to establish.
Synopsis
The study provides new histopathologic findings in women with Essure® devices, suggesting new lines of research to deepen the symptomatology of its users.