Evaluating the role of neurotrophins in the psoriasis and metabolic syndrome relationship

• Published in: Türk dermatoloji dergisi Vol. 11; no. 4; pp. 168 - 173
• Main Authors: Kaya Erdoğan,Hilal, Bulur,Işıl, Saraçoğlu,Zeynep Nurhan, Yiğitaslan,Semra, Çiftçi Sunamak,Evrim, Canaz,Funda, Yıldız,Pınar, Bilgin,Muzaffer
• Format: Journal Article
• Language: English
• Published: Istanbul Türk Dermatoloji Derneği 01-12-2017; Galenos Publishing House
• Subjects: Apoptosis; Biopsy; Blood pressure; Brain-derived neurotrophic factor; Cholesterol; Cytokines; Dermatitis; Disease; Fasting; Gene expression; Growth factors; Inflammation; Inflammatory diseases; Metabolic syndrome; Nervous system; Psoriasis; Rodents; Skin; Studies; Tıp; Triglycerides; Tumor necrosis factor-TNF; Variance analysis; Antalya; Türkiye; metabolic syndrome; immunopathogenesis; sinir büyüme faktörü; nerve growth factor; psoriasis; metabolik sendrom; nörotrofin; immünopatogenez; Brain derived neurotrophic hormon; neurotrophin; Beyin türevli nörotrofik faktör
• ISSN: 1307-7635; 1308-5255
• DOI: 10.4274/tdd.3320

Objective: We aimed to evaluate the role of neurotrophins in relation to metabolic
syndrome (MetS) and psoriasis by determining brain derived neurotrophic hormon
(BDNF), nerve growth factor (NGF), tumor necrosis factor-α (TNF) and interleukin-6 (IL)
levels in serum and skin samples of psoriasis patients and healthy controls.
Methods: The BDNF, NGF, TNF-α and IL-6 levels were assessed using commercially
available ELISA kits. The level of expression BDNF, NGF, TNF-α and IL-6 antibodies was
determined by BDNF, NGF, TNF-α and IL-6 Antibodies.
Results: Thirty nine psoriasis vulgaris patients without MetS risk factors, 21 patients with
psoriasis vulgaris accompanied by MetS and 15 healthy controls were included in the
study. The serum BDNF levels, epidermal and the dermal infiltration levels of BDNF were
significantly higher in the control group than in the psoriasis patients (p=0.017, p=0.019,
p=0.002). There was no difference between the groups in terms of serum NGF, TNF-α
and IL-6 levels (p˃0.05), but the infiltration level of NGF in the epidermis was higher in
the psoriasis patients than the control group and statistically significant difference was
found (p=0.003). Serum BDNF levels, epidermal and dermal BDNF infiltration level and the
epidermal NGF staining intensity were similar among psoriasis patient groups (p>0.05).
Conclusion: The results of our study support the role of neurotrophins in the pathogenesis
of psoriasis. However, serum and tissue BDNF and NGF levels remained unchanged
among the psoriasis groups, suggesting that neurotrophins in the immunopathogenesis
of psoriasis are related to the inflammatory process independently of the metabolic
status.