Ion pair self-assembly composed of polyamidoamine dendrimer and phenylthio acetic acid and its temperature and oxidation-responsive release property

• Published in: International journal of polymeric materials Vol. 73; no. 18; pp. 1579 - 1592
• Main Authors: Wangpimool, Kwanjira, Kim, Jin-Chul
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 11-12-2024; Taylor & Francis Ltd
• Subjects: Acetic acid; Carboxyl group; Fourier transforms; Hydrogen peroxide; Infrared spectroscopy; Ion pairs; NMR; Nuclear magnetic resonance; Oxidation; phase transition temperature; polyamidoamine dendrimer; responsive-release; Self-assembly; temperature
• ISSN: 0091-4037; 1563-535X
• DOI: 10.1080/00914037.2024.2304013

Polyamidoamine (PAMAM) dendrimer/phenylthio acetic acid (PTA) ion pair could be generated when the amino/carboxyl group ratio was 3/7 to 1/9. The chemical shifts on
1
H NMR and FT-IR spectra suggested that PTA interacted ionically with PAMAM. The PTA was oxidized to sulfoxide and sulfone by H
2
O
2
, evidenced by
1
H NMR and FT-IR spectroscopy. The ion pair exhibited upper critical solution temperature (UCST) and air/water interface-active which could decrease upon PTA oxidation. When the medium temperature was higher than the UCST, the substantial release of dye loaded in IPSAM took place in the H
2
O
2
solution.