Inflammatory bowel disease: a focus on the involvement of dietary fats

• Published in: International journal of interferon, cytokine and mediator research Vol. 6; p. 19
• Main Authors: de Silva, Punyanganie S, Korzenik, Joshua R
• Format: Journal Article
• Language: English
• Published: Macclesfield Dove Medical Press Limited 01-01-2014; Taylor & Francis Ltd
• Subjects: Cancer; Diet; Dietary fat; Epidemiology; Fatty acids; Food; Health aspects; Health risk assessment; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Meat; Microbiota; Nutrition research; Oils & fats; Risk factors; Studies; Trans fats; United States > US; Netherlands
• ISSN: 1179-139X; 1179-139X
• DOI: 10.2147/IJICMR.S35997

Inflammatory bowel diseases (IBDs) are chronic immune-mediated diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors. Certain genotypes may develop clinical manifestations under particular environmental influences. There is increasing evidence to suggest that diet is a key environmental factor in IBD, and dietary fats in particular have been implicated in both pro- and anti-inflammatory roles. Previous epidemiological studies have highlighted variable results, most probably due to the complex pathways that may be mediated by fatty acid activity. We aim to review the available studies on dietary fats and IBD pathogenesis and explore mechanisms involved to identify potential opportunities for future research and therapies.