Nodulocystic acne: oral gugulipid versus tetracycline

Twenty patients with nodulocystic acne were randomly allocated to one of two treatment schedules: 1) Tetracycline 500 mg or 2) Tab. Gugulipid (equivalent to 25 mg guggulsterone). Both were taken twice daily for 3 months, and both produced a progressive reduction in the lesions in the majority of pat...

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Bibliographic Details
Published in:	Journal of dermatology Vol. 21; no. 10; p. 729
Main Authors:	Thappa, D M, Dogra, J
Format:	Journal Article
Language:	English
Published:	England 01-10-1994
Subjects:	Acne Vulgaris - drug therapy Acne Vulgaris - metabolism Acne Vulgaris - pathology Administration, Oral Adolescent Adult Commiphora Facial Dermatoses - drug therapy Facial Dermatoses - metabolism Facial Dermatoses - pathology Female Follow-Up Studies Humans Male Plant Extracts - administration & dosage Plant Extracts - therapeutic use Plant Gums Recurrence Sebum - drug effects Sebum - metabolism Tetracycline - administration & dosage Tetracycline - therapeutic use
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Summary:	Twenty patients with nodulocystic acne were randomly allocated to one of two treatment schedules: 1) Tetracycline 500 mg or 2) Tab. Gugulipid (equivalent to 25 mg guggulsterone). Both were taken twice daily for 3 months, and both produced a progressive reduction in the lesions in the majority of patients. With tetracycline, the percentage reduction in the inflammatory lesions was 65.2% as compared to 68% with gugulipid; on comparison, this difference was statistically insignificant (P > 0.05). Follow-up at 3 months showed a relapse in 4 cases on tetracyline and 2 cases on gugulipid. An interesting observation was that the patients with oily faces responded remarkably better to gugulipid.
ISSN:	0385-2407
DOI:	10.1111/j.1346-8138.1994.tb03277.x