Postmortem degradation of demineralized bone matrix osteoinductive potential. Effect of time and storage temperature

The osteoinductive growth factors present in demineralized bone are degraded by tissue enzymes. Storage of rat limbs at low temperature (4 degrees C) before harvesting of bones preserves the osteoinductive potential of such factors. Storage at room temperature for more than 24 hours causes the recov...

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Bibliographic Details
Published in:	Clinical orthopaedics and related research no. 262; p. 281
Main Authors:	Yazdi, M, Bernick, S, Paule, W J, Nimni, M E
Format:	Journal Article
Language:	English
Published:	United States 01-01-1991
Subjects:	Alkaline Phosphatase - analysis Animals Bone Matrix - chemistry Bone Matrix - transplantation Freeze Drying Male Osteogenesis Rats Rats, Inbred Strains Temperature Time Factors
Online Access:	Get more information
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Summary:	The osteoinductive growth factors present in demineralized bone are degraded by tissue enzymes. Storage of rat limbs at low temperature (4 degrees C) before harvesting of bones preserves the osteoinductive potential of such factors. Storage at room temperature for more than 24 hours causes the recovered bone matrix to be biologically inactive, presumably as the result of biodegradation.
ISSN:	0009-921X
DOI:	10.1097/00003086-199101000-00036