Combination sedoanalgesia with remifentanil and propofol versus remifentanil and midazolam for elective cardioversion after coronary artery bypass grafting

• Published in: Advances in therapy Vol. 24; no. 3; pp. 662 - 670
• Main Authors: Yildirim, Vedat, Doganci, Suat, Bolcal, Cengiz, Oz, Bilgehan Savas, Kucukarslan, Nezihi, Cosar, Ahmet, Guzeldemir, M Erdal
• Format: Journal Article
• Language: English
• Published: United States 01-05-2007
• Subjects: Anesthesia Recovery Period; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Atrial Fibrillation - etiology; Atrial Fibrillation - therapy; Coronary Artery Bypass - adverse effects; Drug Combinations; Electric Countershock; Female; Humans; Male; Midazolam - administration & dosage; Midazolam - adverse effects; Midazolam - therapeutic use; Middle Aged; Patient Satisfaction; Piperidines - administration & dosage; Piperidines - adverse effects; Propofol - administration & dosage; Propofol - adverse effects; Propofol - therapeutic use; Prospective Studies; Single-Blind Method
• ISSN: 0741-238X; 1865-8652
• DOI: 10.1007/BF02848791

Postoperative atrial fibrillation (AF) occurs in up to 50% of cardiac surgery patients and represents the most common postoperative arrhythmic complication. Elective cardioversion, a short but painful procedure, remains an option for patients who do not convert to sinus rhythm with medical therapy. Combinations of remifentanil (a potent analgesic with a short elimination time) with propofol (a hypnotic agent) or midazolam (a sedative agent) produce a synergistic interaction. This study was undertaken to compare these combinations in terms of effectiveness and pain relief when given as sedoanalgesia for elective cardioversion. In this prospective, randomized trial, 60 adult patients with postoperative AF after coronary artery bypass grafting were given a single dose of propofol 1 mg/kg combined with remifentanil 0.1 microg/kg (group 1), or midazolam 0.05 mg/kg combined with remifentanil 0.1 microg/kg (group 2). Cardiorespiratory parameters were monitored and recorded. Demographic data were similar (P>.05) and sufficient sedoanalgesia and successful cardioversion were achieved in both groups. Hemodynamic parameters revealed no significant differences between groups (P>.05); however, induction time, time to eye opening, recuperation time, and time to full recovery of psychomotor function were faster in group 1 than in group 2 (P<.05). The remifentanil/propofol combination provided sufficient analgesia, satisfactory hemodynamic stability, and mild respiratory depression, along with faster recovery and discharge times from the intensive care unit.