Electromechanical effects of two low osmolality contrast media, ioxaglate and iohexol, on isolated rat atria

• Published in: Pharmacology & toxicology Vol. 66; no. 4; p. 307
• Main Authors: Tande, P M, Kløw, N E, Refsum, H
• Format: Journal Article
• Language: English
• Published: Denmark 01-04-1990
• Subjects: Animals; Atrial Function; Electrophysiology; Female; Heart - drug effects; Heart - physiology; Heart Atria - drug effects; Iohexol - pharmacology; Ioxaglic Acid - pharmacology; Membrane Potentials - drug effects; Myocardial Contraction - drug effects; Myocardium; Rats; Rats, Inbred Strains
• ISSN: 0901-9928
• DOI: 10.1111/j.1600-0773.1990.tb00753.x

This study aimed at investigating the direct effects of two low osmolality radiographic contrast media, iohexol (non-ionic) and ioxaglate (ionic), on transmembrane action potentials, contractile force and refractoriness of isolated rat atrial preparations. Superfused with 10% solution, ioxaglate induced a biphasic mechanical response, initially decreasing and thereafter increasing contractile force. The same concentration of iohexol only increased contractile force. The two contrast media increased the resting membrane potential, action potential amplitude and rate of depolarization to the same extent. Iohexol prolonged repolarization. Both contrast media decreased the effective refractory period. The direct effects of contrast media on myocardial contractility in this study can explain the different haemodynamic effects of iohexol and ioxaglate in vivo. The observed effects on the action potentials in vitro can explain commonly observed ECG changes during coronary arteriography. The changes in depolarization, repolarization and refractoriness are probably related to the arrhythmogenic properties of these contrast media.