Effects of lasalocid and monensin plus tylosin on serum metabolic hormones and clinical chemistry profiles of beef steers fed a 90% concentrate diet

• Published in: Journal of animal science Vol. 72; no. 4; pp. 1049 - 1058
• Main Authors: Duff, G. C, Galyean, M. L, Branine, M. E, Hallford, D. M
• Format: Journal Article
• Language: English
• Published: United States Am Soc Animal Sci 01-04-1994; Oxford University Press
• Subjects: aliment concentre pour animaux; Animal Feed; Animals; azucar en sangre; beef cattle; Blood; Blood Chemical Analysis - veterinary; blood composition; Blood Glucose - drug effects; Blood Proteins - drug effects; blood serum; blood sugar; Blood Urea Nitrogen; boeuf; bovin de boucherie; buey; bullocks; calcio; calcium; Calcium - blood; Cattle; Cattle - blood; composicion de la sangre; composition du sang; concentrates; Creatinine - blood; desempeno; Diet; Eating; engorde; engraissement; fattening; fosforo; ganado de carne; Growth Hormone - blood; hormonas; hormone; Hormones; insulin; Insulin - blood; insulina; insuline; ionoforos; ionophore; ionophores; Lasalocid - pharmacology; Male; metabolisme de l' azote; metabolisme des mineraux; metabolismo de minerales; metabolismo del nitrogeno; mineral metabolism; monensin; Monensin - pharmacology; monensina; nitrogen metabolism; phosphore; phosphorus; Phosphorus - blood; piensos concentrados; Random Allocation; serum sanguin; sodio; sodium; Sodium - blood; somatotropin; somatotropina; somatotropine; sucre du sang; suero sanguineo; tilosina; tylosin; Tylosin - pharmacology; tylosine; Weight Gain
• ISSN: 0021-8812; 1525-3163
• DOI: 10.2527/1994.7241049x

Fourteen crossbred beef steers (average initial BW 313 +/- 13.1 kg) fed a 90% concentrate diet (as-fed basis) were used to evaluate effects of ionophores on serum metabolic hormones and clinical chemistry profiles. Treatments were no ionophore (C; four steers), lasalocid (L; 33 mg/kg of diet; five steers), and monensin (33 mg/kg of diet) plus tylosin (11 mg/kg of diet; MT; five steers). All steers were adapted to the 90% concentrate diet, after which treatments were applied and blood was sampled via jugular catheters on d 7, 35, 63, 91, and 119 of the trial at 0, 1, 2, 3, 4, 6, 8, and 10 h after feeding. Averaged over sampling days, serum glucose concentrations did not differ (P > 0.10) among treatments at any sampling time (treatment X sampling time, P < 0.05). Averaged across sampling days and times, serum growth hormone, insulin, cholesterol, and triglyceride concentrations did not differ (P > 0.10) among treatments. No major effects of ionophores were noted for serum enzymes or protein fractions. Averaged over sampling times within day (treatment X day interaction, P < 0.10), both L and MT increased (P < 0.05) serum Ca and Na concentrations on d 91 and 119 compared with C. Serum inorganic P was increased (P < 0.10) for L vs MT and for ionophore treatments compared with C (P < 0.10) on several occasions (treatment X day X sampling time interaction, P < 0.05). Results suggest that ionophores do not cause dramatic changes in serum metabolic hormones or clinical chemistry profiles; however, monensin and lasalocid altered serum minerals in beef steers fed a high-concentrate diet.