Kaposi's sarcoma-associated herpesvirus and human herpesvirus 8 (KSHV/HHV8)-associated lymphoma of the bowel : Report of two cases in HIV-positive men with secondary effusion lymphomas

• Published in: The American journal of surgical pathology Vol. 21; no. 6; pp. 719 - 724
• Main Authors: DEPOND, W, SAID, J. W, TASAKA, T, DE VOS, S, KAHN, D, CESARMAN, E, KNOWLES, D. M, KOEFFLER, H. P
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01-06-1997
• Subjects: Adult; AIDS-Related Opportunistic Infections - transmission; AIDS-Related Opportunistic Infections - virology; AIDS/HIV; Biological and medical sciences; Biopsy; Disease Transmission, Infectious; Herpesvirus 8, Human - isolation & purification; HIV Seropositivity - complications; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Immunophenotyping; Intestinal Mucosa - virology; Lymphoma - pathology; Lymphoma - virology; Male; Medical sciences; Sarcoma, Kaposi - pathology; Sarcoma, Kaposi - virology; Immunohistochemistry; Skin disease; HIV-1 virus; Alphaherpesvirinae; Epidemiology; Kaposi sarcoma; Association; Lymphoproliferative syndrome; Intestinal disease; Lentivirinae; Herpesvirus hominis; Human; Immunopathology; Herpesviridae; Gut; Retroviridae; AIDS; Malignant hemopathy; Malignant tumor; Immune deficiency; Lymphoma; Infection; Virus; Case study; Pathology; Viral disease; Digestive diseases; Human immunodeficiency virus
• ISSN: 0147-5185; 1532-0979
• DOI: 10.1097/00000478-199706000-00013

This report describes two cases of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8)-associated lymphomas that primarily involved the large bowel and that secondarily caused malignant effusions. Involvement of the gastrointestinal tract is of interest because epidemiologic evidence suggests that KSHV/HHV-8 may be transmitted via the fecal-oral route, and KSHV/HHV8 DNA has been detected in rectal samples from HIV-positive patients. This report describes two HIV-positive men who developed primary KSHV/ HHV8-associated lymphomas of the bowel. Despite similar morphology and immunophenotype, these cases differ from most KSHV/HHV8-associated primary effusion lymphomas, which present with malignant effusions in the absence of a solid tumor mass. The spectrum of KSHV/HHV8-associated lymphomas is expanded to include a subset of primary bowel lymphomas in individuals infected with human immunodeficiency virus.