Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, a...

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Bibliographic Details
Published in:	Open forum infectious diseases Vol. 11; no. 5; p. ofae250
Main Authors:	Zheng, Shuxuan, Rümke, Lidewij L W, Tello Rubio, Bruno, Rogers, Malbert R C, van Sluis, Geerte L, Kuball, Jürgen H E, Riezebos-Brilman, Annelies, Lebbink, Robert Jan, Verduyn Lunel, Frans M
Format:	Journal Article
Language:	English
Published:	United States 01-05-2024
Subjects:	multidrug resistance HSV-1 foscarnet aciclovir stem cell transplantation
Online Access:	Get full text
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Summary:	We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2328-8957 2328-8957
DOI:	10.1093/ofid/ofae250