Low‐grade B‐cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition

• Published in: Neuropathology Vol. 43; no. 4; pp. 313 - 318
• Main Authors: Lopez, Gianluca, Han, Karam, Magaki, Shino D., Song, Sophie X., Salamon, Noriko, Kahlon, Kanwarpal S., Keselman, Inna, Bari, Ausaf A., Vinters, Harry V.
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01-08-2023; Wiley Subscription Services, Inc
• Subjects: Amyloid; Amyloidosis; B-cell lymphoma; brain; Central nervous system; Epilepsy; Hippocampus; Lymphocytes; lymphoma; meninges; MyD88 protein; Neuroimaging; Occipital lobe; Phenotypes; Plasma cells; Sclerosis; Seizures; amyloid; brain; lymphoma; central nervous system; meninges
• ISSN: 0919-6544; 1440-1789
• DOI: 10.1111/neup.12886

A 65‐year‐old woman with a resolved history of epilepsy due to a motor vehicle accident and hippocampal sclerosis presented with recurrent de novo seizures. Brain imaging demonstrated enhancement in the left parieto‐occipital lobe. At histopathological examination, the lesion displayed a diffuse lymphoid infiltrate comprised of small atypical lymphocytes, plasmacytoid lymphocytes, and scattered plasma cells with amyloid deposition. Pathology workup demonstrated a monotypic B‐cell phenotype of the lymphoid infiltrate, expressing lambda light chain restriction and plasmacytic differentiation without MYD88 mutations. The patient had no systemic evidence of lymphoma, plasma cell dyscrasia, or amyloidosis. A diagnosis of low‐grade B‐cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition was made.