A subtype of the prototypic karyotype in acute myeloid leukemia t (8; 21) (q22; q22), del 9 (q13; q23)

A subtype of the prototypic karyotype in acute myeloid leukemia t (8; 21) (q22; q22), del 9 (q13; q23)

Two patients with acute myeloid leukemia are described in whom G- and C-banding analysis of bone marrow cells revealed, besides the translocation t(8;21), an additional structural anomaly characterized by the deletion of bands q13 to q23 of one chromosome no. 9. Findings in the literature support th...

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Bibliographic Details
Published in:Blut Vol. 40; no. 1; pp. 27 - 32
Main Authors: Hossfeld, D K, Higi, M, Köhler, S, Miller, A, Zschaber, R
Format: Journal Article
Language:English
Published: Germany 01-01-1980
Subjects:
Adult
Chromosome Banding
Chromosome Deletion
Female
Humans
Karyotyping
Leukemia, Myeloid, Acute - genetics
Male
Translocation, Genetic
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Description
Summary:Two patients with acute myeloid leukemia are described in whom G- and C-banding analysis of bone marrow cells revealed, besides the translocation t(8;21), an additional structural anomaly characterized by the deletion of bands q13 to q23 of one chromosome no. 9. Findings in the literature support the proposal that this constellation represents a hitherto unreported subtype of the prototypic karyotype in AML.
ISSN:0006-5242
1432-0584
DOI:10.1007/BF01028361