Efficient synthesis of alkyl aryl ketones & ketals via palladium-catalyzed regioselective arylation of vinyl ethers

The combination of Pd(OAc)(2) with 1,3-bis(diphenylphosphino)propane (dppp) in ethylene glycol constitutes a high-performance catalytic system for highly regioselective arylation of a range of electron-rich vinyl ethers by aryl bromides to provide, upon hydrolysis, alkyl aryl ketones and cyclic keta...

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Bibliographic Details
Published in:	Organic & biomolecular chemistry Vol. 8; no. 9; p. 2012
Main Authors:	Liu, Mingcui, Hyder, Zeynab, Sun, Yawei, Tang, Weijun, Xu, Lijin, Xiao, Jianliang
Format:	Journal Article
Language:	English
Published:	England 01-01-2010
Subjects:	Acetates - chemistry Catalysis Ketones - chemical synthesis Ketones - chemistry Molecular Structure Organometallic Compounds - chemistry Stereoisomerism Vinyl Compounds - chemistry
Online Access:	Get more information
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Summary:	The combination of Pd(OAc)(2) with 1,3-bis(diphenylphosphino)propane (dppp) in ethylene glycol constitutes a high-performance catalytic system for highly regioselective arylation of a range of electron-rich vinyl ethers by aryl bromides to provide, upon hydrolysis, alkyl aryl ketones and cyclic ketals in good yields with up to 3.75 x 10(5) TON and 15625 h(-1) TOF.
ISSN:	1477-0539
DOI:	10.1039/c001004a