Amino Appended Coumarin Composites for Pb2+ Capturing in Aqueous Medium

• Published in: Journal of fluorescence Vol. 32; no. 1; pp. 109 - 114
• Main Authors: Sharma, Nidhi, Gulati, Ashu
• Format: Journal Article
• Language: English
• Published: New York Springer US 2022; Springer Nature B.V
• Subjects: Amines; Analytical Chemistry; Aqueous solutions; Binding; Biochemistry; Biocompatibility; Biological and Medical Physics; Biomedical and Life Sciences; Biomedicine; Biophysics; Biotechnology; Coumarin; Explosives detection; Human body; NMR; Nuclear magnetic resonance; Original Article; Receptors; Room temperature; Toxicity; Chelation; Pb; Amines; Coumarin; Heavy metals
• ISSN: 1053-0509; 1573-4994
• DOI: 10.1007/s10895-021-02827-9

The C1-C3 receptors were synthesized by using coumarin and amines viz., 1-butylpiperazine (1), cis-myrtanylamine (2), and 3-methyldiphenyl amine (3) at room temperature without using harsh conditions. All the probes show beautiful and strong binding with Pb
2+
ions among all the tested essential elements of human body. The binding is clearly seen and confirmed in UV-visible, NMR and HPLC studies. Also, all the substituted amines (1-3) are well known bioactives viz., piperazine as anthelmintic, cis-myrtanyl use for cannabinoid receptor (CB2) antagonists, 3-methyldiphenyl is used in probes for selective detection of explosive nitroaromatic compounds further increases their sensitivity for use as Pb
2+
sensor. As they are already well in use for research on human body metabolomics their future introduction as sensors in the human body for lead toxicity is highly favourable.