Mitogen-induced multiplication of lymphocytes from newborn infants

Marked lymphocyte responses to PHA, ConA and PWM were demonstrated in the first week of life. Prematurity up to 30 weeks gestational age did not influence the results. There were only small variations in the responses from day to day, no sex differences, and no differences between infants who were s...

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Bibliographic Details
Published in:	European journal of pediatrics Vol. 134; no. 1; pp. 23 - 26
Main Authors:	Haneberg, B, Bertnes, E, Ulstein, M
Format:	Journal Article
Language:	English
Published:	Germany 01-06-1980
Subjects:	Adrenal Cortex Hormones - pharmacology Concanavalin A - pharmacology Humans Immunity, Cellular Immunoglobulin M - analysis Infant, Low Birth Weight Infant, Newborn Infant, Premature Lymphocytes - drug effects Mitogens - pharmacology Phytohemagglutinins - pharmacology Pokeweed Mitogens - pharmacology Sex Factors
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Summary:	Marked lymphocyte responses to PHA, ConA and PWM were demonstrated in the first week of life. Prematurity up to 30 weeks gestational age did not influence the results. There were only small variations in the responses from day to day, no sex differences, and no differences between infants who were small for gestational age of appropriate weight. Newborn infants with high serum IgM-concentrations had reduced lymphocyte responses to ConA, possibly through the influence of ConA on B-lymphocytes. Infants of mothers who had received corticosteroids prior to delivery had lower mean responses to all 3 mitogens, but the differences between the steroid- and comparable non-steroid groups were not significant. The results suggest that newborn infants have functioning cellular immune mechanisms.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0340-6199 1432-1076
DOI:	10.1007/BF00442398