Acute saline expansion lowers blood pressure of early DOCA salt hypertensive rats

• Published in: Pflügers Archiv Vol. 390; no. 3; pp. 260 - 261
• Main Authors: Villamil, M F, Amorena, C, Ponce, J, Müller, A, Taquini, A C
• Format: Journal Article
• Language: English
• Published: Germany 01-06-1981
• Subjects: Animals; Blood Pressure - drug effects; Blood Volume - drug effects; Desoxycorticosterone; Extracellular Space - physiopathology; Hypertension - chemically induced; Hypertension - physiopathology; Inulin - physiology; Male; Rats; Sodium Chloride - pharmacology
• ISSN: 0031-6768; 1432-2013
• DOI: 10.1007/BF00658272

Changes in blood pressure and body fluids volume caused by an acute saline load were studied in 6 normal and 7 DOCA-salt early hypertensive rats having normal inulin space and plasma volume. After loading, blood pressure increased in the normal group (+23 mm Hg) and fell (-17 mm Hg) in the DOCA-salt group. Expansion of extracellular fluid volume was similar in both groups but expansion of plasma volume was twice as high in the DOCA-salt than in the normal group. The results are compatible with an inhibition of a volume-sensitive vasopressor mechanism possibly involving vasopressin.